Are fertility issues hereditary?
Here are some examples of common and rare genetic causes of infertility.
Some fertility issues are genetic. Genetic diseases can run in families, but some can occur for the first time in an individual and from then can be passed down to their future offspring. Here are some examples of common and rare genetic causes of infertility.
Endometriosis
Endometriosis affects 1 in 9 females and is 7 times more common in women whose mother or sister had it. A family history of endometriosis implies that our genes carry some influence. No specific one gene has yet been identified as to blame and environmental factors also play a part.
Polycystic Ovarian Syndrome (PCOS)
PCOS is a multifactorial condition but can run in families. PCOS can be associated with a family history of relatives developing Type 2 diabetes later in life and gestational diabetes in pregnancy.
Chromosomal problems
Chromosome structural rearrangements like translocations and inversions can develop in us or can be inherited from a parent. Having a translocation is a cause of both infertility and recurrent miscarriages and can also sometimes increase your risk of having a baby affected by a severe genetic syndrome. A genetic blood test called a karyotype can diagnose this issue. Chromosome structural rearrangements can be carried by the male or female so both partners need to be tested to rule it out. A translocation in sperm can cause all the same problems as a translocation in eggs – half a baby’s DNA comes from each parent. This kind of problem can have delayed detection if investigating the male partner of an infertile couple is delayed. It is so important to look deeply into both men and women suffering infertility – even when the semen analysis looks normal on paper as it usually does in this circumstance.
Male fertility problems needing IVF
Studies have proved that unfortunately, male factor infertility can be passed down genetically. Sons conceived with the help of fertility treatments like IVF and sperm micro-injection (ICSI) are more likely to require the same kind of help to conceive themselves.
Inherited genetic diseases
Problems and mutations in individual genes can cause hereditary infertility. An example is the FRAX1 gene which expands slowly when passed down through families and eventually goes from normal length, to pre-mutation length and eventually causes the disease fragile X syndrome. In women, carrying a Fragile-X pre-mutation causes low ovarian reserve, premature ovarian insufficiency and early menopause.
“Unexplained infertility”
There are literally thousands of individual genes and proteins involved in fertility in both men and women. We are learning more and more about them. It is likely that a lot of what we now label unexplained infertility is in fact due to a specific genetic issue that we just haven’t discovered yet. Happily, because IVF helps us to skip over a lot of steps in the baby making process that occur in nature, we can solve the problem of unexplained infertility for many couples by getting around it despite not yet fully understanding it.
Written by Dr Raelia Lew
RANZCOG Board Certified CREI Fertility specialist, Gynaecologist and the Director of Women’s Health Melbourne.
Co-host of the Knocked Up Podcast, Co-founder of Lovers intimate wellness solutions. Raelia has a PhD in Preconception Health Promotion and Genetic Screening. Raelia is a leading Australian expert in IVF and egg freezing, pioneering a bespoke model of care.